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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > UPF-1069CAS：1048371-03-4
Molecular Formula：C17H13NO3
Molecular Weight：279.29
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1048371-03-4 |
| Name | UPF-1069 |
| Molecular Formula | C17H13NO3 |
| Molecular Weight | 279.29 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00012952 |
| SMILES | O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O |
| Target Point | PARP |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | UPF 1069 is a selective PARP2 inhibitor. |
| Biological Activity | UPF 1069 是一种 PARP 抑制剂，对 PARP-1 和 PARP-2 的 IC50 值分别为 8 和 0.3 μM。[1] |
| Data Literature Source | [1]. Pellicciari R，et al. On the way to selective PARP-2 inhibitors. Design，synthesis，and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3(6):914-23. [2]. Moroni F，et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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