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CAY-10603

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Cat.No：IC3330 Solarbio

CAS：1045792-66-2

Molecular Formula：C₂₂H₃₀N₄O₆

Molecular Weight：446.5

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	1045792-66-2
Name	CAY-10603
Molecular Formula	C₂₂H₃₀N₄O₆
Molecular Weight	446.5
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17010286
SMILES	O=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	CAY10603 is a potent and selective HDAC6 inhibitor.
Biological Activity	CAY10603 是一种有效的，选择性的 HDAC6 抑制剂，IC50 值为 2 pM；CAY10603 同时可抑制 HDAC1，HDAC2，HDAC3，HDAC8 和 HDAC10 的活性，IC50 值分别为 271，252，0.42，6851，90.7 nM[1-2]。
IC50	HDAC1:271nM;HDAC2:252nM;HDAC3:0.42nM;HDAC6:0.002nM;HDAC10:90.7nM;HDAC8:6851nM [1-2]
Data Literature Source	[1]. Kozikowski AP，et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem. 2008 Aug 14;51(15):4370-3. [2]. Wang Z，et al. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncol Rep. 2016 Jul;36(1):589-97.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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