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Niraparib

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Cat.No：IN1480 Solarbio

CAS：1038915-60-4

Molecular Formula：C₁₉H₂₀N₄O

Molecular Weight：320.39

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	1038915-60-4
Name	Niraparib
Molecular Formula	C₁₉H₂₀N₄O
Molecular Weight	320.39
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17779309
SMILES	NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O
Target Point	PARP
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	Niraparib is a selective PARP-1 and PARP-2 inhibitor.
Biological Activity	Niraparib (MK-4827) 是高效的 PARP1 和 PARP2 抑制剂, IC50 分别为 3.8 nM 和 2.1 nM[1-3]。
IC50	PARP-2:2.1nM (IC50) PARP-1:3.8nM (IC50) V-PARP:330nM (IC50) TANK-1:570nM (IC50) PARP-3:1300nM (IC50) [1-3]
Data Literature Source	[1]. Jones P， et al. Discovery of 2-{4-[ (3S) -piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827) : a novel oral poly (ADP-ribose) polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26; 52 (22) :7170-85. [2]. Bridges KA， et al. Niraparib (MK-4827) ， a novel poly (ADP-Ribose) polymerase inhibitor， radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15; 5 (13) :5076-86. [3]. Wang L， et al. MK-4827， a PARP-1/-2 inhibitor， strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec; 30 (6) :2113-20
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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