Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Entresto

Entresto

Manual Download

Cat.No：IE1290 Solarbio

CAS：936623-90-4

Molecular Formula：C₂₄H₂₉N₅O₃·C₂₄H₂₉NO₅·₅/₂H₂O·₃Na

Molecular Weight：961.02

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	936623-90-4
Name	Entresto
Molecular Formula	C₂₄H₂₉N₅O₃·C₂₄H₂₉NO₅·₅/₂H₂O·₃Na
Molecular Weight	961.02
Solubility	Soluble in Water/DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 000-000-0
MDL	MFCD28900676
SMILES	O=C(CCC([O-])=O)N([C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C)C(OCC)=O)[H].[O-]C([C@@H](N(C(CCCC)=O)CC3=CC=C(C4=CC=CC=C4C5=NN=N[N-]5)C=C3)C(C)C)=O.[Na+].[Na+].[Na+].[2.5H2O]
Target Point	Angiotensin Receptor；RAAS
Passage	GPCR & G Protein
Background	It is a dual inhibitor of angiotensin II receptor and enkephalinase.
Biological Activity	Entresto是血管紧张素II受体和脑啡肽酶的双抑制剂。[1-3]
Data Literature Source	[1]. Huo H，et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605. [2]. von Lueder TG，et al. Angiotensin receptor neprilysin inhibitor Entresto attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circ Heart Fail. 2015 Jan;8(1):71-8. [3]. Bai HY，et al. Pre-treatment with Entresto，an orally active angiotensin receptor neprilysin inhibitor，prevents ischemic brain damage. Eur J Pharmacol. 2015 Sep 5;762:293-8.
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.