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Application：ELISA
Reactivity：Mouse
Sample Type：Serum，Plasma，Cell Culture Supernatant
Sensitivity：3.9pg/mL
Storage：2-8℃，6 months
Gene ID：13136
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| Name | Mouse CD55 ELISA Kit |
| Storage | 2-8℃，6 months |
| Detection Target | CD55 |
| Sample Type | Serum，Plasma，Cell Culture Supernatant |
| Reactivity | Mouse |
| Application | ELISA |
| Quantitative/Qualitative | Quantitative |
| Detection Range | 7.8-500pg/mL |
| Sensitivity | 3.9pg/mL |
| Precision | Both intra-plate and inter-plate variation coefficients were less than 10% |
| Recovery | 80%-120% |
| Assay Time | 3h15min |
| Swiss Prot | Q61475 |
| Gene ID | 13136 |
| Background | CD55，also well known as decay-accelerating factor (DAF)，is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system，but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis，decrease of complement mediated tumor cell lysis，autocrine loops for cell rescue and evasion of apoptosis，neoangiogenesis，invasiveness，cell motility. It is commonly hijacked by invading pathogens，including many enteroviruses and uropathogenic Escherichia coli，to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases，thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated，seven-transmembrane lymphocyte receptor，CD97，which is a receptor mediating attachment and infection of several viruses and bacteria. In addition，it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo，and thus may be implicated in immune and tumor biology. |
| Unit | Kit |
| Specification | 48T 96T |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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