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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > PD-123319CAS：130663-39-7
Molecular Formula：C31H32N4O3
Molecular Weight：508.61
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：Solid
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| CAS | 130663-39-7 |
| Name | PD-123319 |
| Molecular Formula | C31H32N4O3 |
| Molecular Weight | 508.61 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥97% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00896427 |
| SMILES | O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O |
| Target Point | Angiotensin Receptor |
| Passage | GPCR & G Protein |
| Background | PD123319 is a potent and selective AT2 angiotensin II receptor antagonist. |
| Biological Activity | PD 123319是血管紧张素II受体拮抗剂，IC50为34 nM[1-4]。 |
| IC50 | 34nM(AT2 Receptor)[1] |
| Data Literature Source | [1]. Blankley CJ，et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60. [2]. Boulay G，et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41(4):809-15 [3]. Estrup TM，et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92. [4]. Brillante DG，et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6(2):102-6. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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