{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > LosartanCAS：114798-26-4
Molecular Formula：C22H23ClN6O
Molecular Weight：422.91
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 114798-26-4 |
| Name | Losartan |
| Molecular Formula | C22H23ClN6O |
| Molecular Weight | 422.91 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 601-329-8 |
| MDL | MFCD00865831 |
| SMILES | OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2 |
| InChIKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) |
| PubChem CID | 3961 |
| Target Point | Angiotensin Receptor |
| Passage | GPCR & G Protein |
| Background | Losartan is an angiotensin II receptor antagonist that competes with angiotensin II for binding to the AT1 receptor. |
| Biological Activity | Losartan 是血管紧张素II受体拮抗剂，与血管紧张素II竞争性结合AT1受体，IC50为20 nM。[1-5] |
| Data Literature Source | [1]. Burnier，M. Angiotensin II type 1 receptor blockers. Circulation，2001. 103(6): p. 904-12. [2]. Ashry，O.，et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol，2014. [3]. Choi，C.H.，et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol，2012. 126(1): p. 124-31. [4]. Habashi，J.P.，et al. Losartan，an AT1 antagonist，prevents aortic aneurysm in a mouse model of Marfan syndrome. Science，2006. 312(5770): p. 117-21. [5]. Campbell，D.J.，et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol，1995. 26(2): p. 233-40. |
| Unit | Bottle |
| Specification | 100mg 200mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
