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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Valproic AcidCAS：99-66-1
Molecular Formula：C8H16O2
Molecular Weight：144.21
Storage：Store at 2-8℃，2 years
Purity：≥98%
Appearance：Colorless to light yellow Liquid
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| CAS | 99-66-1 |
| Name | Valproic Acid |
| Molecular Formula | C8H16O2 |
| Molecular Weight | 144.21 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Colorless to light yellow Liquid |
| Storage | Store at 2-8℃，2 years |
| Density | 0.9g/mL |
| EC | EINECS 202-777-3 |
| MDL | MFCD00002672 |
| SMILES | CCCC(CCC)C(O)=O |
| InChIKey | NIJJYAXOARWZEE-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10) |
| PubChem CID | 3121 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Valproic acid is a histone deacetylase (HDAC) inhibitor. Valproic acid activates Notch-1 signaling. |
| Biological Activity | Valproic acid 是一种 HDAC 抑制剂，IC50 值为 0.5-2 mM，抑制 HDAC1 的活性，(IC50，400 μM)，同时可诱导 HDAC2 的降解；Valproic acid抑制VEGF，VEGFR2和bFGF的mRNA和蛋白质表达。Valproic acid sodium salt 可用于癫痫、双相情感障碍和偏头痛等的研究。[1-5] |
| Data Literature Source | [1]. Han BR，et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [2]. Zhang ZH，et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [3]. Cohen OS，et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [4]. Avery LB，et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass，Hepatic Fat Accumulation，and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [5]. Valproic acid，et al. Histone deacetylase is a direct target of valproic acid，a potent anticonvulsant，mood stabilizer，and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. |
| Unit | Bottle |
| Specification | 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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