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RG-108

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Cat.No：IR0790 Solarbio

CAS：48208-26-0

Molecular Formula：C₁₉H₁₄N₂O₄

Molecular Weight：334.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	48208-26-0
Name	RG-108
Molecular Formula	C₁₉H₁₄N₂O₄
Molecular Weight	334.33
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD08705332
SMILES	O=C(N1[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)C4=CC=CC=C4C1=O
InChIKey	HPTXLHAHLXOAKV-INIZCTEOSA-N
InChI	InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1
PubChem CID	702558
Target Point	DNA Methyltransferase
Passage	Epigenetics
Background	RG-108 is a DNA methyltransferase inhibitor.
Biological Activity	RG108 是一种非核苷的 DNA 甲基转移酶 (DNA methyltransferase) 抑制剂，IC50 值为 115 nM。[1-3]
Data Literature Source	[1]. Brueckner B，et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 2005 Jul 15;65(14):6305-11. [2]. Schirrmacher E，et al. Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug Chem. 2006 Mar-Apr;17(2):261-6. [3]. Pasha Z，et al. Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells. PLoS One. 2011;6(8):e23667
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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