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AK-7

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Cat.No：IA4020 Solarbio

CAS：420831-40-9

Molecular Formula：C₁₉H₂₁BrN₂O₃S

Molecular Weight：437.35

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	420831-40-9
Name	AK-7
Molecular Formula	C₁₉H₂₁BrN₂O₃S
Molecular Weight	437.35
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD03140195
SMILES	O=S(N1CCCCCC1)(C2=CC(C(NC3=CC(Br)=CC=C3)=O)=CC=C2)=O
InChIKey	IYAYHZZWYNXHEQ-UHFFFAOYSA-N
InChI	InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
PubChem CID	1328033
Target Point	SIRT2
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	AK 7 is a SIRT2 inhibitor.
Biological Activity	AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor， with an IC50 of 15.5 μM.[1-3]
Data Literature Source	[1]. Taylor DM， et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. [2]. Chopra V， et al. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntingtons disease mouse models. Cell Rep. 2012 Dec 27;2(6):1492-7. [3]. Szego EM， et al. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. Neurobiol Aging. 2017 Aug;56:7-16.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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