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C-646

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Cat.No：IC3420 Solarbio

CAS：328968-36-1

Molecular Formula：C₂₄H₁₉N₃O₆

Molecular Weight：445.42

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	328968-36-1
Name	C-646
Molecular Formula	C₂₄H₁₉N₃O₆
Molecular Weight	445.42
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD01311760
SMILES	O=C(O)C1=CC=C(N2N=C(C)/C(C2=O)=C\C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)C=C1
InChIKey	HEKJYZZSCQBJGB-UNOMPAQXSA-N
InChI	InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
PubChem CID	1285941
Target Point	Histone Acetyltransferase;p300/CBP
Passage	Epigenetics
Background	C646 is a histone acetyltransferase inhibitor that inhibits p300.
Biological Activity	C646 是选择性，竞争性的 histone acetyltransferase p300 抑制剂，Ki 值为 400 nM，对其他的乙酰转移酶作用较小[1-3]。
Data Literature Source	[1]. Bowers EM，et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28;17(5):471-82. [2]. Oike T，et al. C646，a selective small molecule inhibitor of histone acetyltransferase p300，radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014 May;111(2):222-7. [3]. Zheng WW，et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014 Aug;32(8):2278-89
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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