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JIB-04

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Cat.No：IJ0190 Solarbio

CAS：199596-05-9

Molecular Formula：C₁₇H₁₃ClN₄

Molecular Weight：308.77

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	199596-05-9
Name	JIB-04
Molecular Formula	C₁₇H₁₃ClN₄
Molecular Weight	308.77
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD26936344
SMILES	ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1
Target Point	Histone Demethylase
Passage	Epigenetics
Background	It is a broad-spectrum selective inhibitor of Jumonji histone demethylase.
Biological Activity	JIB-04 是 Jumonji 组蛋白去甲基酶 (Jumonji histone demethylase) 广谱抑制剂, 能抑制 JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C 和 JMJD2D 的活性, 其 IC50 值分别为 230, 340, 855, 445, 435, 1100 和 290 nM[1]。
IC50	IC50: 230nM (JARID1A) ， 445nM (JMJD2A) ， 435nM (JMJD2B) ， 1100nM (JMJD2C) ， 290nM (JMJD2D) ， 340nM (JMJD2E) ， 855nM (JMJD3) [1]
Data Literature Source	[1]. Wang L， et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun， 2013. 4: p. 2035. [2]. Banelli B， et al. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. Oncotarget. 2017 Apr 4.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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