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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > DBET 6CAS：1950634-92-0
Molecular Formula：C42H45ClN8O7S
Molecular Weight：841.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1950634-92-0 |
| Name | DBET 6 |
| Molecular Formula | C42H45ClN8O7S |
| Molecular Weight | 841.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31692407 |
| SMILES | O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4 |
| Target Point | BRD4 |
| Passage | Epigenetics |
| Background | DBET6 is a BET bromodomains PROTAC degrader. |
| Biological Activity | 是一种具有良好的细胞通透性的BET bromodomainsPROTAC降解剂，与BRD4结合的IC50值为14 nM。dBET6 还可诱导c-MYC的下调和凋亡。[1] |
| Data Literature Source | [1] Winter GE，et al. Mol Cell. 2017，67(1):5-18.e19. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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