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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > A-485CAS：1889279-16-6
Molecular Formula：C25H24F4N4O5
Molecular Weight：536.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1889279-16-6 |
| Name | A-485 |
| Molecular Formula | C25H24F4N4O5 |
| Molecular Weight | 536.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31619258 |
| SMILES | O=C(N1CC(N([C@@H](C)C(F)(F)F)CC2=CC=C(F)C=C2)=O)[C@]3(OC1=O)C4=CC=C(NC(NC)=O)C=C4CC3 |
| Target Point | p300/CBP |
| Passage | Epigenetics |
| Background | A-485 is a potent and selective p300/CBP catalytic inhibitor. |
| Biological Activity | A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT)，respectively[1]. |
| IC50 | 9.8nM(p300)，2.6nM(CBP)[1] |
| Data Literature Source | [1]. Lasko LM，et al. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 Oct 5;550(7674):128-132. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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