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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > TAK-733CAS：1035555-63-5
Molecular Formula：C17H15F2IN4O4
Molecular Weight：504.23
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1035555-63-5 |
| Name | TAK-733 |
| Molecular Formula | C17H15F2IN4O4 |
| Molecular Weight | 504.23 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD24386349 |
| SMILES | O=C1C(C(NC2=CC=C(I)C=C2F)=C(F)C(N3C)=O)=C3N=CN1C[C@@H](O)CO |
| Target Point | MEK |
| Passage | MAPK |
| Background | TAK-733 is a potent and selective MEK inhibitor. |
| Biological Activity | TAK-733 是一种有效的选择性 MEK 抑制剂，IC50 为 3.2 nM。[1-2] |
| IC50 | MEK:3.2nM |
| Data Literature Source | [1]. Dong Q，et al. Discovery of TAK-733，a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9. [2]. Micel LN，et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14(2):317-25. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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