{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > TamibaroteneCAS：94497-51-5
Molecular Formula：C22H25NO3
Molecular Weight：351.44
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 94497-51-5 |
| Name | Tamibarotene |
| Molecular Formula | C22H25NO3 |
| Molecular Weight | 351.44 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1806241-263-5 |
| MDL | MFCD00866188 |
| SMILES | O=C(C1=CC=C(C=C1)C(NC2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=O)O |
| Target Point | RAR（RARα，RARβ） |
| Passage | Metabolic Enzyme&Protease |
| Background | Tamibarotene is a retinoic acid receptor alpha/beta (RARalpha/beta) agonist. |
| Biological Activity | Tamibarotene是视黄酸受体α/β (RARα/β)的激动剂，比RARγ的选择性高。[1-5] |
| Data Literature Source | [1]. Wang X，et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8(16):26245-26255. [2]. Toyama T，et al. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts，Endothelial Cells，and Immune Cells. J Invest Dermatol. 2016 Feb;136(2):387-98. [3]. Jin Y，et al. Tamibarotene modulates the local immune response in experimental periodontitis. Int Immunopharmacol. 2014 Dec;23(2):537-45. [4]. Lv XR，et al. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells. Biochem J. 2013 Nov 15;456(1):35-46. [5]. Kitaoka K，et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology. 2013 Sep;72:58-65 |
| Unit | Bottle |
| Specification | 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
