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Troglitazone

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Cat.No：IT2140 Solarbio

CAS：97322-87-7

Molecular Formula：C₂₄H₂₇NO₅S

Molecular Weight：441.54

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	97322-87-7
Name	Troglitazone
Molecular Formula	C₂₄H₂₇NO₅S
Molecular Weight	441.54
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00878416
SMILES	O=C(SC1CC(C=C2)=CC=C2OCC3(C)OC(C(CC3)=C4C)=C(C)C(C)=C4O)NC1=O
InChIKey	GXPHKUHSUJUWKP-UHFFFAOYSA-N
InChI	InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
PubChem CID	5591
Target Point	PPAR
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	It is a novel potent PPARγ agonist with anti-inflammatory and antitumor activity.
Data Literature Source	[1]. Willson TM，et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [2]. Fujita M，et al. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J Exp Clin Cancer Res. 2017 Jul 3;36(1):91. [3]. Nazim UM，et al. PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. Oncotarget. 2017 Apr 18;8(16):26819-26831.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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