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WHI-P154

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Cat.No：IW0130 Solarbio

CAS：211555-04-3

Molecular Formula：C₁₆H₁₄BrN₃O₃

Molecular Weight：376.2

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	211555-04-3
Name	WHI-P154
Molecular Formula	C₁₆H₁₄BrN₃O₃
Molecular Weight	376.2
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 809-014-9
MDL	MFCD02179366
SMILES	OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br
InChIKey	CBIAKDAYHRWZCU-UHFFFAOYSA-N
InChI	InChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)
PubChem CID	3795
Target Point	EGFR，JAK3
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
Background	WHI-P154 is a potent EGFR inhibitor with modest inhibition of JAK3 activity.
Biological Activity	WHI-P154 是一种有效的 EGFR 抑制剂，同时可适度的抑制 JAK3 的活性，IC50 值分别为 4 nM 和 1.8 μM。[1-2]
IC50	EGFR:4nM;JAK3:1.8μM [1-2]
Data Literature Source	[1]. Changelian PS，et al. The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. Epub 2007 Dec 19. [2]. Zhang H，et al. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci. 2014 Aug;105(8):1071-8.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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