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Zafirlukast

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Cat.No：IZ0230 Solarbio

CAS：107753-78-6

Molecular Formula：C₃₁H₃₃N₃O₆S

Molecular Weight：575.68

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	107753-78-6
Name	Zafirlukast
Molecular Formula	C₃₁H₃₃N₃O₆S
Molecular Weight	575.68
Solubility	Soluble in DMSO ≥10mg/mL
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00864775
SMILES	O=C(OC1CCCC1)NC2=CC3=C(N(C)C=C3CC4=CC=C(C(NS(=O)(C5=CC=CC=C5C)=O)=O)C=C4OC)C=C2
InChIKey	YEEZWCHGZNKEEK-UHFFFAOYSA-N
InChI	InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
PubChem CID	5717
Target Point	Leukotriene Receptor
Passage	GPCR & G Protein
Background	Zafirlukast is a potent leukotriene D4 (LTD4) receptor antagonist
Biological Activity	Zafirlukast 是一种有效的具有口服活性的白三烯 D4 (LTD4) 受体拮抗剂[1-2]
Data Literature Source	[1]. Finnerty JP，et al. Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219，a potent leukotriene D4 receptor antagonist. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):746-9. [2]. Gunning WT，et al. Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res. 2002 Aug 1;62(15):4199-201
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 25mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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