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Daporinad

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Cat.No：ID2570 Solarbio

CAS：658084-64-1

Molecular Formula：C₂₄H₂₉N₃O₂

Molecular Weight：391.51

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	658084-64-1
Name	Daporinad
Molecular Formula	C₂₄H₂₉N₃O₂
Molecular Weight	391.51
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD10565943
SMILES	C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
Target Point	Nampt
Passage	Metabolic Enzyme&Protease
Background	It is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase).
Biological Activity	FK866是烟酰胺磷酸核糖转移酶 (NMPRTase) 的有效抑制剂， IC50 为 0.09 nM。[1-3]
Data Literature Source	[1]. Cea M，et al. Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood. 2012 Oct 25;120(17):3519-29. [2]. Magnone M，et al. NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. J Biol Chem. 2012 Jun 15;287(25):21067-81. [3]. Thakur BK，et al. Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochem Biophys Res Commun. 2012 Aug 3;424(3):371-7
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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