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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > IrsogladineCAS：57381-26-7
Molecular Formula：C9H7Cl2N5
Molecular Weight：256.09
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 57381-26-7 |
| Name | Irsogladine |
| Molecular Formula | C9H7Cl2N5 |
| Molecular Weight | 256.09 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD00866871 |
| SMILES | NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1 |
| InChIKey | ATCGGEJZONJOCL-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16) |
| PubChem CID | 3752 |
| Target Point | mAChR，PDE |
| Passage | Neuronal Signaling;GPCR & G Protein;Metabolic Enzyme&Protease |
| Background | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. |
| Biological Activity | Irsogladine， an anti-ulcer drug， suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils.Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor[1-3] |
| Data Literature Source | [1]. Kyoi T，Noda K，Oka M，Ukai Y. Irsogladine，an anti-ulcer drug，suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 2004 Nov 19;76(1):71-83. [2].Kyoi T，Oka M，Noda K，Ukai Y. Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci. 2004 Aug 27;75(15):1833-42. [3]. Ueda F，Ban K，Ishima T. Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor. J Pharmacol Exp Ther. 1995 Aug;274(2):815-9 |
| Unit | Bottle |
| Specification | 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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