English Name |
Anti-CYP4F11 Polyclonal Antibody |
Chinese Name |
细胞色素P450家族4F亚家族多肽11抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:1000-3000. IHC 1:100-300. |
Target |
CYP4F11 |
Synonyms |
Cytochrome P450 4F11, CP4FB_HUMAN, cytochrome P450, family 4, subfamily F, polypeptide 11, cytochrome P450, subfamily IVF, polypeptide 11 |
Background |
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids.Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation . Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil. |
Swiss Prot |
Q9HBI6 |
Gene ID |
57834 |
Subcellular Location |
Cytoplasm |
Immunogen |
A synthetic peptide of human CYP4F11 |
Public Immunogen Range |
410-460/524aa |
Calculated MW |
60kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human Rat Mouse |
Application |
WB IHC |