| English Name |
Anti-FZD5/8 Polyclonal Antibody |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Predicted Reactivity |
Zebrafish |
| Dilution Ratio |
WB 1:1000-3000. IHC 1:100-300. |
| Target |
FZD5/8 |
| Synonyms |
C2orf31, DKFZP434E2135, Frizzled homolog 5, Frizzled-5, Frizzled5, Fz 5, Fz-5, Fz5, FZD 5, hFz5, FZD5, FZD5_HUMAN, FzE 5, FzE5, HFZ 5, HFZ5, MGC129692, Seven transmembrane receptor frizzled 5, Uncharacterized protein C2orf31, Wnt receptor, FZD8, Frizzled 8, FZ 8 |
| Background |
Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). |
| Swiss Prot |
Q13467/Q9H461 |
| Gene ID |
7855/8325 |
| Subcellular Location |
Cytoplasm |
| Immunogen |
A synthetic peptide of Human FZD5/8 |
| Public Immunogen Range |
30-80/585aa |
| Calculated MW |
65/73kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human Rat Mouse |
| Application |
IHC WB |
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