| Gene Name |
PTPN1 |
| Synonyms |
PTP1B;tyrosine-protein phosphatase non-receptor type 1 |
| English Name |
Recombinant human PTPN1 protein |
| Full Name |
protein tyrosine phosphatase，non-receptor type 1 |
| Chinese Name |
非受体型蛋白酪氨酸磷酸酶1 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P18031 |
| Gene ID |
5770 |
| Reactivity |
Human Mouse Rat (Chicken) |
| Molecular Weight |
38kDa |
| Interval Range |
103-435aa |
| Background |
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence.PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues.Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity.PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase.This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.Two transcript variants encoding different isoforms have been found for this gene. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
English
中文
Manual Download
