| Gene Name |
GHRL |
| Synonyms |
Appetite regulating hormone，Ghrelin Obestatin，GHRL，Growth hormone secretagogue，Motilin related peptide，MTLRP，obestatin，Protein M46 |
| English Name |
Recombinant human GHRL protein |
| Full Name |
Appetite-regulating hormone |
| Chinese Name |
食欲调节激素 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q9UBU3 |
| Gene ID |
51738 |
| Reactivity |
Human Mouse Rat (Bovine Cat Dog Pig Goat) |
| Molecular Weight |
13kDa |
| Interval Range |
1-117aa |
| Background |
This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin.Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis.Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin).Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion.It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated.Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism.Alternative splicing results in multiple transcript variants.In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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