| Gene Name |
RYBP |
| Synonyms |
RYBP;AAP1;APAP-1;DEDAF;YEAF1;RING1 and YY1-binding protein |
| English Name |
Recombinant human RYBP protein |
| Full Name |
RING1 and YY1 binding protein |
| Chinese Name |
RING1 与YY1结合蛋白 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q8N488 |
| Gene ID |
23429 |
| Reactivity |
Human Mouse |
| Molecular Weight |
25kDa |
| Interval Range |
1-228aa |
| Background |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females.May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity).Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes.May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis.May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1.May bind to DNA (By similarity).May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 . |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
No activity experimental data, to be verified. |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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