| Gene Name |
HLA-DRB3 |
| Synonyms |
HLA-DRB3;HLA-DR1B;HLA-DR3B;major histocompatibility complex，class II，DR beta 3 |
| English Name |
Recombinant human HLA-DRB3 protein |
| Full Name |
major histocompatibility complex，class II，DR beta 3 |
| Chinese Name |
HLA-Ⅱ类组织相容性抗原DR-β3链 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P01911 |
| Gene ID |
3125 |
| Reactivity |
Human |
| Molecular Weight |
30kDa |
| Interval Range |
1-266aa |
| Background |
HLA-DRB3 belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane.It plays a central role in the immune system by presenting peptides derived from extracellular proteins.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The beta chain is approximately 26-28 kDa and its gene contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5.The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted.There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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