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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > 1400W dihydrochlorideCAS：214358-33-5
Molecular Formula：C10H15N3·2HCl
Molecular Weight：250.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 214358-33-5 |
| Name | 1400W dihydrochloride |
| Molecular Formula | C10H15N3·2HCl |
| Molecular Weight | 250.17 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03428622 |
| SMILES | CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl |
| Target Point | iNOS，nNOS，eNOS |
| Passage | Immunology & Inflammation |
| Background | 1400W Dihydrochloride is a potent and highly selective inhibitor of inducible nitric oxide synthase (iNOS) |
| Biological Activity | 1400W是一种不可逆的抑制剂或是一种具有积极缓慢的可逆性的抑制剂，抑制iNOS。1400W (N-(3-(Aminomethyl)benzyl)acetamidine) 是iNOS的抑制剂，与iNOS缓慢、紧密地结合，具有选择性。[1-4] |
| IC50 | Ki: 7nM(iNOS)，2μM(nNOS)，50μM(eNOS)[1] |
| Data Literature Source | [1] Garvey EP，et al. J Biol Chem. 199，272(8):4959-63. [2] Ersoz N，et al. Ren Fail. 2009，31(8):704-10. [3] Sen N，et al. Nat Cell Biol. 2008，10(7):866-73. [4] Thomsen LL，et al. Cancer Res. 1997，57(15):3300-4. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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