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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > AZD-8330CAS：869357-68-6
Molecular Formula：C16H17FIN3O4
Molecular Weight：461.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 869357-68-6 |
| Name | AZD-8330 |
| Molecular Formula | C16H17FIN3O4 |
| Molecular Weight | 461.23 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 642-441-7 |
| MDL | MFCD18384989 |
| SMILES | CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO |
| Target Point | MEK |
| Passage | MAPK |
| Background | AZD8330 is a potent and non-competitive MEK1/MEK2 inhibitor. |
| Biological Activity | AZD8330 是一种有效的非竞争性的 MEK1/MEK2 抑制剂，IC50 为 7 nM。[1-2] |
| IC50 | MEK1:7nM;mEK2:7nM [1-2] |
| Data Literature Source | [1]. Cohen RB，et al. A phase I dose-finding，safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9. [2]. Baranski Z，et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6(11-12):503-12. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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