CU-CPT22
Cat.No:IC3830 Solarbio
CAS:1416324-85-0
Molecular Formula:C19H22O7
Molecular Weight:362.37
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Off-white to yellow Solid
Qty:
Size:
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CU-CPT22CAS:1416324-85-0
Molecular Formula:C19H22O7
Molecular Weight:362.37
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Off-white to yellow Solid
Qty:
Size:
CAS | 1416324-85-0 |
Name | CU-CPT22 |
Molecular Formula | C19H22O7 |
Molecular Weight | 362.37 |
Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water < 0.1mg/mL |
Purity | ≥98% |
Appearance | Off-white to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD26406409 |
SMILES | O=C(C(C=C1O)=CC2=CC(OC)=C(O)C(O)=C2C1=O)OCCCCCC |
Target Point | Toll-like Receptor (TLR) |
Passage | Immunology & Inflammation |
Background | CU-CPT22 is the first probe of the complex between Toll-like receptors TLR1 and TLR2. |
Biological Activity | CU-CPT22抑制Pam3CSK4诱导的TLR1/2激活,IC50为0.58 ± 0.09 μM,而对TLR2/6没有显著抑制作用。它对PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1和PLK4仅具微弱的(或无)非特异性抑制作用。[1-3] |
IC50 | TLR1/2(Cell-free):0.58μM [1] |
Data Literature Source | [1] Cheng K,et al. Angew Chem Int Ed Engl. 2012,51(49):12246-9. [2] Ohno K,et al. Am J Physiol Heart Circ Physiol. 2017,313(6):H1130-H1142. [3] Bock S,et al. Pharmacol Res. 2016,105:44-53 |
Unit | Bottle |
Specification | 5mg 10mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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