{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > Dabrafenib MesylateCAS：1195768-06-9
Molecular Formula：C23H20F3N5O2S2·CH4O3S
Molecular Weight：615.67
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1195768-06-9 |
| Name | Dabrafenib Mesylate |
| Molecular Formula | C23H20F3N5O2S2·CH4O3S |
| Molecular Weight | 615.67 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 689-167-4 |
| MDL | MFCD20922872 |
| SMILES | CC(C)(C)C1=NC(C2=C(F)C(NS(C3=C(F)C=CC=C3F)(=O)=O)=CC=C2)=C(C4=CC=NC(N)=N4)S1.CS(=O)(O)=O |
| Target Point | Raf |
| Passage | MAPK |
| Background | It is an ATP-competitive Raf inhibitor. |
| Biological Activity | Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.7 nM, 5.2 nM and 6.3 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.[1-2] |
| IC50 | B-RafV600E:0.7nM;B-RAF:5.2nM;C-RAF:6.3nM [1] |
| Data Literature Source | [1] Rheault TR，et al. ACS Med Chem Lett. 2013，4(3):358-62. [2] Alastair J. King，et al. PLoS One. 2013，8(7): e67583. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
