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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Diphenyleneiodonium ChlorideCAS：4673-26-1
Molecular Formula：C12H8ClI
Molecular Weight：314.55
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 4673-26-1 |
| Name | Diphenyleneiodonium Chloride |
| Molecular Formula | C12H8ClI |
| Molecular Weight | 314.55 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00214165 |
| SMILES | C12=CC=CC=C1C3=CC=CC=C3[I+]2.[Cl-] |
| Target Point | TRP Channel; NADPH Oxidase; Reactive Oxygen Species |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Diphenyleneiodonium Chloride is an NADPH oxidase (NOX) inhibitor and a TRPA1 activator. |
| Biological Activity | Diphenyleneiodonium chloride 是一种 NADPH 氧化酶 (NOX) 抑制剂，也是一种 TRPA1 激活剂，EC50 值在 1 至 3 μM 之间。[1-2] |
| IC50 | EC50: 1 to 3μM(TRPA1)[1] |
| Data Literature Source | [1]. Suzuki H，et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94. [2]. He YF，et al. Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. Brain Res. 2013 Jan 25;1492:108-21 |
| Unit | Bottle |
| Specification | 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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