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Elafibranor

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Cat.No：IE1580 Solarbio

CAS：923978-27-2

Molecular Formula：C₂₂H₂₄O₄S

Molecular Weight：384.49

Storage：Store at 2-8℃，2 years

Purity：≥98%

Appearance：White to light yellow Liquid

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Product Information

CAS	923978-27-2
Name	Elafibranor
Molecular Formula	C₂₂H₂₄O₄S
Molecular Weight	384.49
Solubility	Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL
Purity	≥98%
Appearance	White to light yellow Liquid
Storage	Store at 2-8℃，2 years
MDL	MFCD27987940
SMILES	CC(C)(OC1=C(C)C=C(/C=C/C(C2=CC=C(SC)C=C2)=O)C=C1C)C(O)=O
Target Point	PPAR
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	Elafibranor is an agonist of PPARα/δ.
Biological Activity	Elafibranor是 PPARα/δ 的激动剂，EC50 分别为 45 和 175 nM。[1-3]
IC50	PPAR-α:45nM(EC50);PPAR-δ:175nM(EC50)[1-3]
Data Literature Source	[1]. Liu ZM，et al. Early investigational drugs targeting PPAR-α for the treatment of metabolic disease.Expert Opin Investig Drugs. 2015 May;24(5):611-21. [2]. Ratziu V，et al. Elafibranor，an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ，Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology. 2016 May;150(5):1147-1159. [3]. Hanf R，et al. The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.Diab Vasc Dis Res. 2014 No
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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