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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > GDC-0623CAS：1168091-68-6
Molecular Formula：C16H14FIN4O3
Molecular Weight：456.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1168091-68-6 |
| Name | GDC-0623 |
| Molecular Formula | C16H14FIN4O3 |
| Molecular Weight | 456.21 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 604-604-1 |
| MDL | MFCD25976760 |
| SMILES | FC(C=C(I)C=C1)=C1NC2=C(C(NOCCO)=O)C=CC3=CN=CN23 |
| Target Point | MEK |
| Passage | MAPK |
| Background | GDC-0623 is a novel, potent, selective, and ATP-competitive MEK1 inhibitor. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth, and constitutive activation of this pathway has been implicated in many cancers. |
| Biological Activity | GDC-0623 (RG 7421) is a potent， ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM， +ATP)， and displays 6-fold weaker potency against HCT116 (KRAS (G13D)， EC50=42 nM) versus A375 (BRAFV600E， EC50=7 nM).[1-2] |
| Data Literature Source | [1]. Hatzivassiliou G， et al. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature. 2013 Sep 12;501(7466):232-6. [2]. Takahashi RH， et al. Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623， a MAPK/ERK Kinase Inhibitor. Drug Metab Dispos. 2015 Dec;43(12):1929-1933. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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