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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > JNK-IN-8CAS：1410880-22-6
Molecular Formula：C29H29N7O2
Molecular Weight：507.59
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1410880-22-6 |
| Name | JNK-IN-8 |
| Molecular Formula | C29H29N7O2 |
| Molecular Weight | 507.59 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD06657552 |
| SMILES | CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3 |
| Target Point | JNK |
| Passage | MAPK |
| Background | JNK-IN-8 is a potent JNK inhibitor that inhibits JNK1, JNK2 and JNK3. |
| Biological Activity | JNK-IN-8 是一种有效的 JNK 抑制剂，抑制 JNK1，JNK2 和 JNK3，IC50 分别为 4.7 nM，18.7 nM 和 1 nM。[1-2] |
| IC50 | JNK3:1nM;JNK1:4.7nM;JNK2:18.7nM [1-2] |
| Data Literature Source | [1]. Zhang T，et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. [2]. Liu Q，et al. Developing irreversible inhibitors of the protein kinase cysteinome. Chem Biol. 2013 Feb 21;20(2):146-59 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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