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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > PranlukastCAS：103177-37-3
Molecular Formula：C27H23N5O4
Molecular Weight：481.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 103177-37-3 |
| Name | Pranlukast |
| Molecular Formula | C27H23N5O4 |
| Molecular Weight | 481.5 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-616-4 |
| MDL | MFCD00864631 |
| SMILES | O=C(NC1=C2C(C(C=C(C3=NNN=N3)O2)=O)=CC=C1)C4=CC=C(OCCCCC5=CC=CC=C5)C=C4 |
| InChIKey | NBQKINXMPLXUET-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32) |
| PubChem CID | 4887 |
| Target Point | Leukotriene Receptor |
| Passage | GPCR & G Protein |
| Background | It is a potent and competitive selective leukotriene antagonist. |
| Biological Activity | Pranlukast 是一种高效的竞争性的选择性 leukotriene 拮抗剂。Pranlukast 抑制 [3H]LTE4，[3H]LTD4 和 [3H]LTC4 与肺膜结合，Ki 分别为 0.63±0.11，0.99±0.19 和 5640±680 nM。[1-3] |
| Data Literature Source | [1]. Obata T，et al. In vitro antagonism of ONO-1078，a newly developed anti-asthma agent，against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol. 1992 Nov;60(3):227-37. [2]. Fang SH，et al. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells. Acta Pharmacol Sin. 2012 Dec;33(12):1511-7. [3]. Ogata M，et al. Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice. Infect Immun. 1992 Jun;60(6):2432-7 |
| Unit | Bottle |
| Specification | 25mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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