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My CartApplication：ELISA
Reactivity：Mouse
Sample Type：Serum，Plasma，Cell Culture Supernatant
Sensitivity：39pg/mL
Storage：2-8℃，6 months
Gene ID：13649
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| Name | Mouse EGFR ELISA Kit |
| Storage | 2-8℃，6 months |
| Detection Target | EGFR |
| Sample Type | Serum，Plasma，Cell Culture Supernatant |
| Reactivity | Mouse |
| Application | ELISA |
| Quantitative/Qualitative | Quantitative |
| Detection Range | 78.13-5000pg/mL |
| Sensitivity | 39pg/mL |
| Precision | Both intra-plate and inter-plate variation coefficients were less than 10% |
| Recovery | 80%-120% |
| Assay Time | 3h15min |
| Swiss Prot | Q01279 |
| Gene ID | 13649 |
| Background | The EGF R subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER-1，ErbB1，or ErbB)，ErbB2 (Neu，HER-2)，ErbB3 (HER-3)，and ErbB4 (HER-4). All family members are type I transmembrane glycoproteins with an extracellular ligand binding domain containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain followed by multiple tyrosine autophosphorylation sites. The human EGF R cDNA encodes a 1210 amino acid (aa) precursor with a 24 aa signal peptide，a 621 aa extracellular domain (ECD)，a 23 aa transmembrane segment，and a 542 aa cytoplasmic domain. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse. Within the ECD，human EGF R shares 88% aa sequence identity with mouse and rat EGF R. It shares 43% - 44% aa sequence identity with the ECD of human ErbB2，ErbB3，and ErbB4. EGF R binds a subset of the EGF family ligands，including EGF，amphiregulin，TGF-alpha，betacellulin，epiregulin，HB-EGF，and epigen. Ligand binding induces EGF R homodimerization as well as heterodimerization with ErbB2，resulting in kinase activation，heterodimerization tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling regulates multiple biological functions including cell proliferation，differentiation，motility，and apoptosis. EGF R is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. |
| Unit | Kit |
| Specification | 48T 96T |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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