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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Almorexant HydrochlorideCAS：913358-93-7
Molecular Formula：C29H31F3N2O3·HCl
Molecular Weight：549.02
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 913358-93-7 |
| Name | Almorexant Hydrochloride |
| Molecular Formula | C29H31F3N2O3·HCl |
| Molecular Weight | 549.02 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01646135 |
| SMILES | CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O.Cl |
| Target Point | Orexin Receptor (OX Receptor) |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Almorexant Hydrochloride is a potent orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist. |
| Biological Activity | Almorexant HCl (ACT-078573)是口服有效的双重orexin receptor 拮抗剂，其作用于受体 OX1 和 OX2 的 IC50 分别为 6.6 nM 和 3.4 nM。[1-3] |
| IC50 | OX2 receptor: 3.4nM;OX1 receptor: 6.6nM[1] |
| Data Literature Source | [1] Brisbare-Roch C，et al. Nat Med. 2007，13(2)，150-155. [2] Nollet M，et al. Neuropsychopharmacology. 2012，37(10)，2210-2221. [3] Anderson RI，et al. Front Neurosci. 2014，8，33. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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