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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > CGS-21680 HydrochlorideCAS：124431-80-7
Molecular Formula：C23H29N7O6·HCl
Molecular Weight：535.98
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 124431-80-7 |
| Name | CGS-21680 Hydrochloride |
| Molecular Formula | C23H29N7O6·HCl |
| Molecular Weight | 535.98 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00078573 |
| SMILES | O=C(O)CCC1=CC=C(CCNC2=NC3=C(N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O4)C(N)=N2)C=C1.Cl |
| Target Point | Adenosine Receptor |
| Passage | GPCR & G Protein |
| Background | CGS-21680 Hydrochloride is a selective adenosine A2A receptor agonist. |
| Biological Activity | CGS 21680 Hydrochloride是选择性的腺苷A2A受体激动剂，Ki为27 nM。[1-4] |
| Data Literature Source | [1]. Bao R，et al. Adenosine and the adenosine A2A receptor agonist，CGS21680，upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75. [2]. Zhang M，et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36. [3]. Melani A，et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72. [4]. Komaki S，et al. Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522(1):21-4 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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