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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Conivaptan HydrochlorideCAS：168626-94-6
Molecular Formula：C32H26N4O2·HCl
Molecular Weight：535.04
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 168626-94-6 |
| Name | Conivaptan Hydrochloride |
| Molecular Formula | C32H26N4O2·HCl |
| Molecular Weight | 535.04 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD00945712 |
| SMILES | O=C(C1=CC=CC=C1C2=CC=CC=C2)NC3=CC=C(C(N4CCC(N=C(C)N5)=C5C6=CC=CC=C64)=O)C=C3.Cl |
| Target Point | Vasopressin Receptor |
| Passage | GPCR & G Protein |
| Background | It is a non-peptide vasopressin receptor antagonist. |
| Biological Activity | Conivaptan hydrochloride 是一种非肽段类的 vasopressin receptor 拮抗剂，能够抑制大鼠肝脏的 V1A 受体 和 肾脏的 V2 受体，Ki 值分别为 0.48 和 3.04 nM。[1-3] |
| Data Literature Source | [1]. Wada K，et al. Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure. Eur J Pharmacol. 2005 Jan 10;507(1-3):145-51. Epub 2005 Jan 1. [2]. Fernandez-Varo G，et al. Effect of the V1a/V2-AVP receptor antagonist，Conivaptan，on renal water metabolism and systemic hemodynamics in rats with cirrhosis and ascites. J Hepatol. 2003 Jun;38(6):755-61. [3]. Yatsu T，et al. Cardiovascular and renal effects of conivaptan hydrochloride (YM087)，a vasopressin V1A and V2 receptor antagonist，in dogs with pacing-induced congestive heart failure. Eur J Pharmacol. 1999 Jul 9;376(3):239-46 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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