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NPS-2143

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Cat.No：IN1520 Solarbio

CAS：284035-33-2

Molecular Formula：C₂₄H₂₅ClN₂O₂

Molecular Weight：408.92

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	284035-33-2
Name	NPS-2143
Molecular Formula	C₂₄H₂₅ClN₂O₂
Molecular Weight	408.92
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	N#CC1=C(OC[C@@H](CNC(C)(CC2=CC=C3C=CC=CC3=C2)C)O)C=CC=C1Cl
Target Point	CaSR
Passage	GPCR & G Protein
Background	NPS-2143 is a selective calcium-sensing receptor (CaSR) antagonist.
Biological Activity	NPS-2143是选择性的钙敏感受体 (CaSR) 拮抗剂，IC50 为 43 nM。[1-5]
Data Literature Source	[1]. Nemeth EF，et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31. [2]. Rybczynska A，et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191(1):189-95. [3]. Ohsu T，et al. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010 Jan 8;285(2):1016-22 [4]. Nakajima S，et al. Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells. Mol Nutr Food Res. 2012 May;56(5):753-60 [5]. Sun J，et al. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1309-17.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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