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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Phenoxybenzamine HydrochlorideCAS：63-92-3
Molecular Formula：C18H22ClNO·HCl
Molecular Weight：340.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 63-92-3 |
| Name | Phenoxybenzamine Hydrochloride |
| Molecular Formula | C18H22ClNO·HCl |
| Molecular Weight | 340.3 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-569-7 |
| MDL | MFCD00599580 |
| SMILES | CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | Phenoxybenzamine Hydrochloride is a selective inhibitor of alpha-adrenoceptor and calmodulin. |
| Biological Activity | Phenoxybenzamine hydrochloride 是具有选择行的 α-adrenoceptor 和 calmodulin 的抑制剂，是一种常用的抗高血压药。[1-4] |
| Data Literature Source | [1]. Lenox，R.H.，et al，Alpha 2-adrenergic receptor-mediated regulation of adenylate cyclase in the intact human platelet. Evidence for a receptor reserve. Mol Pharmacol，1985. 27(1): p. 1-9. [2]. Byon HJ，et al. Dexmedetomidine Inhibits Phenylephrine-induced Contractions via Alpha-1 Adrenoceptor Blockade and Nitric Oxide Release in Isolated Rat Aortae. Int J Med Sci. 2017 Feb 7;14(2):143-149. [3]. Lin XB，et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37(3):2901-8. [4]. Rau TF，et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15(1):1402-17. |
| Unit | Bottle |
| Specification | 250mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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