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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Plerixafor 8HydrochlorideCAS：155148-31-5
Molecular Formula：C28H54N8·8HCl
Molecular Weight：794.47
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 155148-31-5 |
| Name | Plerixafor 8Hydrochloride |
| Molecular Formula | C28H54N8·8HCl |
| Molecular Weight | 794.47 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 828-184-5 |
| MDL | MFCD04974488 |
| SMILES | [H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.N1(CCCNCCNCCCNCC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3 |
| InChIKey | UEUPDYPUTTUXLJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H |
| PubChem CID | 65014 |
| Target Point | CXCR |
| Passage | Immunology & Inflammation;GPCR & G Protein |
| Background | Plerixafor 8Hydrochloride is a selective CXCR4 antagonist. |
| Biological Activity | Plerixafor octahydrochloride是一种选择性的 CXCR4 拮抗剂， IC50 为 44 nM。[1-4] |
| Data Literature Source | [1]. Zabel BA，et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183(5):3204-11. [2]. Mercurio L，et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55. [3]. Yang J，et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926. [4]. Chu PY，et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10(7):e0133616 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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