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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > ReversineCAS：656820-32-5
Molecular Formula：C21H27N7O
Molecular Weight：393.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light green to green Solid
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| CAS | 656820-32-5 |
| Name | Reversine |
| Molecular Formula | C21H27N7O |
| Molecular Weight | 393.23 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light green to green Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09953189 |
| SMILES | C1(NC2=CC=C(N3CCOCC3)C=C2)=NC(NC4CCCCC4)=C5C(NC=N5)=N1 |
| Target Point | AuroraKinase |
| Passage | Cell Cycle |
| Background | Reversine is an ATP-competitive Aurorakinase inhibitor. |
| Biological Activity | Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂，作用于 Aurora A，Aurora B 和 Aurora C，IC50 分别为 400，500 和 400 nM。[1-2] |
| Data Literature Source | [1]. D'Alise AM，et al. Reversine，a novel Aurora kinases inhibitor，inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008 May;7(5):1140-9. [2]. Qin HX，et al. Synergistic antitumor activity of reversine combined with aspirin in cervical carcinoma in vitro and in vivo. Cytotechnology. 2013 Aug;65(4):643-53. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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