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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > SiponimodCAS：1230487-00-9
Molecular Formula：C29H35F3N2O3
Molecular Weight：516.6
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1230487-00-9 |
| Name | Siponimod |
| Molecular Formula | C29H35F3N2O3 |
| Molecular Weight | 516.6 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142651 |
| SMILES | O=C(C1CN(CC2=CC=C(/C(C)=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)C=C2CC)C1)O |
| Target Point | S1P Receptor（S1P1，S1P5） |
| Passage | GPCR & G Protein |
| Background | Siponimod is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. |
| Biological Activity | BAF312 (Siponimod)是一种二代S1P受体激动剂，选择性作用于S1P1和S1P5受体，EC50分别为0.39 nM和0.98 nM，比作用于S1P2， S1P3和S1P4受体选择性高1000倍以上。[1-3] |
| IC50 | S1P1 receptor: 0.39nM(EC50) [1] |
| Data Literature Source | [1] Gergely P，et al. Br J Pharmacol，2012，167(5)，1035-1047. [2] Pan S，et al. ACS Med，Chem，Lett，2013，4 (3)，333–337. [3] Lewis ND，et al. J Immunol，2013，190(7)，3533-3540. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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