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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > INCB-054329CAS：1628607-64-6
Molecular Formula：C19H16N4O3
Molecular Weight：348.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1628607-64-6 |
| Name | INCB-054329 |
| Molecular Formula | C19H16N4O3 |
| Molecular Weight | 348.36 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C1NC2=C3N1[C@@H](C4=NC=CC=C4)COC3=C(C5=C(C)ON=C5C)C=C2 |
| Target Point | BET |
| Passage | Epigenetics |
| Background | INCB-054329 is a BET inhibitor. |
| Biological Activity | INCB054329 (INCB-054329, INCB-54329)是BET抑制剂，对BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1和BRDT-BD2的IC50分别为44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM和63 nM。[1-3] |
| Data Literature Source | [1] Stubbs MC，et al. Clin Cancer Res. 2019，25(1):300-311. [2] Phillip CC Liu，et al. AACR Cancer Res. 2015，75(15 Suppl):Abstract nr 3523. [3] Wilson AJ，et al. Gynecol Oncol. 2018，149(3):575-584. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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