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PFI3

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Cat.No：IP3040 Solarbio

CAS：1819363-80-8

Molecular Formula：C₁₉H₁₉N₃O₂

Molecular Weight：321.37

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	1819363-80-8
Name	PFI3
Molecular Formula	C₁₉H₁₉N₃O₂
Molecular Weight	321.37
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28100807
SMILES	OC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1
Target Point	Epigenetic Reader Domain（SMARCA2/4）
Passage	Epigenetics
Background	PFI-3 is a potent and selective SMARCA2/4 bromodomain inhibitor.
Biological Activity	PFI-3是高效选择性，可渗透细胞的SMARCA2/4溴结构域抑制剂，Kd值为89 nM。[1-3]
IC50	Kd: 89nM(SMARCA2/4)[1]
Data Literature Source	[1]. Vangamudi B，et al. The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. Cancer Res. 2015 Sep 15;75(18):3865-78. [2]. Fedorov O，et al. Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. Sci Adv. 2015 Nov 13;1(10):e1500723. [3]. Gerstenberger BS，et al. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. J Med Chem. 2016 May 26;59(10):4800-11
Unit	Bottle
Specification	2mg 5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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