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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > GSK126CAS：1346574-57-9
Molecular Formula：C31H38N6O2
Molecular Weight：526.67
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1346574-57-9 |
| Name | GSK126 |
| Molecular Formula | C31H38N6O2 |
| Molecular Weight | 526.67 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23381067 |
| SMILES | O=C(C1=CC(C2=CC=C(N3CCNCC3)N=C2)=CC4=C1C(C)=CN4[C@@H](C)CC)NCC5=C(C)C=C(C)NC5=O |
| Target Point | Histone Methyltransferase（EZH2） |
| Passage | Epigenetics |
| Background | GSK126 is a potent and highly selective inhibitor of EZH2 methyltransferase. |
| Biological Activity | GSK126 是一种有效，选择性的 EZH2 甲基转移酶抑制剂，IC50 为 9.9 nM。[1-2] |
| Data Literature Source | [1]. McCabe MT，et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012 Dec 6;492(7427):108-12. [2]. Sato T，et al. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep. 2013 May 29;3:1911 |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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