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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > I-BET-762CAS：1260907-17-2
Molecular Formula：C22H22ClN5O2
Molecular Weight：423.9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1260907-17-2 |
| Name | I-BET-762 |
| Molecular Formula | C22H22ClN5O2 |
| Molecular Weight | 423.9 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22417091 |
| SMILES | ClC1=CC=C(C2=N[C@@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1 |
| Target Point | BET proteins |
| Passage | Epigenetics |
| Background | I-BET151 is a BET bromodomain inhibitor. |
| Biological Activity | GSK 525762A是 BET 溴结构域 抑制剂，IC50 为32.5-42.5 nM。[1] |
| IC50 | 32.5-42.5nM(BET)[1] |
| Data Literature Source | [1]. Nicodeme E，et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23. [2]. Asangani IA，et al. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature. 2014 Jun 12;510(7504):278-82. [3]. Chaidos A，et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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