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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > PinometostatCAS：1380288-87-8
Molecular Formula：C30H42N8O3
Molecular Weight：562.71
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1380288-87-8 |
| Name | Pinometostat |
| Molecular Formula | C30H42N8O3 |
| Molecular Weight | 562.71 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD24849416 |
| SMILES | NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN([C@@H]4C[C@H](CCC5=NC6=C(C=CC(C(C)(C)C)=C6)N5)C4)C(C)C)O3 |
| Target Point | DOT1L |
| Passage | Epigenetics |
| Background | It is a S-adenosylmethionine (SAM) competitive inhibitor of the protein methyltransferase DOT1L. |
| Biological Activity | Pinometostat (EPZ-5676) 是有效的DOT1L组蛋白甲基转移酶抑制剂， Ki 为 80 pM。[1-2] |
| Data Literature Source | [1]. Daigle SR，et al. Potent inhibition of DOT1L as treatment for MLL-fusion leukemia. Blood. 2013 Jun 25. [Epub ahead of print] [2]. Klaus CR，et al. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. J Pharmacol Exp Ther. 2014 Sep;350(3):646-56 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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